D

General: Etiology unknown; autosomal recessive; occurs in both sexes with onset in early infancy; characterized by intermittent simultaneous occurrence of diarrhea and dermatitis with failure to thrive.

Ocular: Loss of eyebrows; blepharitis; ectropion; loss of eyelashes; photophobia; conjunctivitis; scattered superficial corneal opacities; keratitis; lacrimal punctal stenosis; corneal superficial punctate lesions, nebulous subepithelial opacities and linear epithelial erosions.

Clinical: Symmetrical skin eruptions on hands, feet, elbows, knees, and buttocks usually dry up to an erythematosquamous type; glossitis and stomatitis; alopecia; paronychia with nail dystrophy; gastrointestinal disturbances; diarrhea (intermittent).

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Gellis SS, Feingold M. Acrodermatitis enteropathica. Am J Dis Child 1969; 117:201.

Matta CS, et al. Eye manifestations in acrodermatitis enteropathica. Arch Ophthalmol 1975; 93:140-l42.

Prabriputaloong A, Prakitrittranon W Corneal involvement in acrodermatitis enteropathica: a case report. J Med Assoc Thailand 1992; 75:423-427.

Racz P, et al. Bilateral cataract in acrodermatitis enteropathica. J Pediatr Ophthalmol Strabismus 1979; 16:180-l82.

Sandstrom B, et al. Acrodermatitis enteropathica, zinc metabolism, copper status and immune function. Arch Pediatr Adolesc Med 1994; 148:980-985.