Devic syndrome (ophthalmoencephalomyelopathy; optic myelitis; neuromyelitis optica)  363

General: Etiology unknown; frequent between the ages of 20 and 50 years; mo 151h75b rtality rate up to 50%; associated with chickenpox.

Ocular: Ptosis is rare; ocular muscle palsy (rare); abducens and oculomotor palsy; paralysis of conjugate gaze; blindness; onset usually very sudden in one eye, followed soon by blindness in the other eye; miosis; bilateral optic neuritis (unilateral involvement is rare); optic atrophy; pupillary dysfunction.

Clinical: Prodromal signs: headache; sore throat; fever and malaise; ascending myelitis with resulting pain, which may be severe; numbness; weakness; paralysis.

Ahasan HA, et al. Neuromyelitis optics (Devic's disease) following chicken pox. Trop Doct 1994; 24:75-76.

al-Deeb SM, et al. Devic's neuromyelitis optica and varicella. J Neurol 1993; 240:450-451.

Chusid MJ, et al. Neuromyelitis optica (Devic disease) following varicella infection. J Pediatr

Devic E. Myelite Aigue Dorso-lumbaire, avec Nevrite Optique; Autopsie. Cong Fr Med 1894-l895; 1:434.

Francois J. Ocular manifestations in demyelinating diseases. Adv Ophthalmol 1979; 39:1-36.

Hauser SL. Multiple sclerosis and other demyelinating diseases. In: Isselbacher KJ, et al., eds. Harrison’s Principles of Internal Medicine, 13th ed. New York: McGraw-Hill, 1994:2287-2294.

Kinney EL, et al. Devic's syndrome and systemic lupus erythematosus: a case report with necropsy. Arch Neurol 1979; 36:643-644.

Sadig SA, Miller JR. Devic syndrome. In: Rowland LP, ed. Merritt’s Textbook of Neurology, 9th ed. Baltimore: Williams & Wilkins, 1995:825.

Williamson PM. Neuromyelitis optica following infectious mononucleosis. Proc Aust Assoc Neurol 1975; 12: 153-l55.