German syndrome (fetal trimethadione; tridione)

General: Both sexes affected; prenatal onset; occurs when trimethadione or paramethadione is taken during pregnancy.

Ocular: Eyebrows up-slanted.

Clinical: Mild brachycephaly; short upturned nose; prominent forehead; cleft lip and palate; micrognathia; ear abnormalities; tetralogy of Fallot; genital abnormalities; hypospadias; hypertrophic clitoris; abnormalities of skin, gastrointestinal, renal, and skeletal systems.

German J, et al. Trimethadione and human teratogenesis. Teratology 1970; 3:349-361.