Goodpasture syndrome

General: Chronic, relapsing pulmonary hemosiderosis, often in association with fatal glomerulonephritis; rare; occurs in young males.

Ocular: Episcleritis; juxtapapillary subretinal neovascular membranes; superficial retinal hemorrhages; bilateral peripheral retinoschisis; hemorrhagic and/or exudative retinopathy; nonrhegmatogenous retinal detachment (rare).

Clinical: Cough with recurrent hemoptysis; dyspnea; pulmonary infiltrates; hypochromic iron deficiency anemia; glomerulonephritis; progressive renal failure; diffuse hemorrhagic inflammation of lung.

Bergrem H, et al. Goodpasture's syndrome: a report of seven patients including long-term follow-up of three who received a kidney transt. Am J Med 1980; 68:54-58.

Hoscheit AM, et al. Nomhegmatogenous retinal detachment in Goodpasture's syndrome: a case report and discussion of the clinicopathologic entity. J Am Optom Assoc 1993; 64:563-567.

Jampol LM, et al. Ocular Clinical findings and basement membrane changes in Goodpasture's syndrome. Am J Ophthalmol 1975; 79:452.

Rowe PA, et al. Ophthalmic features of fourteen cases of Goodpasture's syndrome. Nephron 1994; 68:52-56.