Loffler syndrome (eosinophilic pneumonitis)

General: Etiology unknown, but such consi 828f53i derations as drug hypersensitivity, parasites, mycoses, and periarteritis nodosa have been advanced; eosinophilia up to 80%; condition self-limited and benign; may occur after using crack cocaine, after administration of medications such as minocycline, or as an idiopathic disorder.

Ocular: Endophthalmitis; retinal infarction with hemorrhages and exudates.

Clinical: Dry cough; shortness of breath; increased body temperature; weight loss; malaise; anorexia; fever; dyspnea; pleural rales; pericardial effusion; prolonged expiration; wheezing.

Bando T, et al. Minocycline-induced pneumonitis with bilateral hilar lymphadenopathy and pleural effusion. Int Med 1994; 33:177-l79.

Geeraets WJ. Ocular Syndromes. 3rd ed. Philadelphia: Lea & Febiger, 1976.

Loffier W. Zur Differenatial Diagnose der Lungeninfiltrierungen: Uber fluchtige Succedaninfiltrate (mit Eosinophilie). Beitr Klin Tuberkulose 1032; 79:338.

Nadeem S, et al. Loffier's syndrome secondary to crack cocaine. Chest 1994; 105:1599-l600.

Nishio M, et al. Idiopathic acute eosinophilic pneumonia. Int Med 1992; 31:1139-l143.

Warnock ML, et al. Chronic eosinophilic pneumonia: a manifestation of allergic aspergillosis. Am J Clin Pathol 1974; 62:73.