Morning glory syndrome (hereditary central glial anomaly of the optic disk)

General: No hereditary factor; rare; anomaly of optic disk with deep excavation resembling the flower for which syn 646e42g drome is named.

Ocular: Strabismus; abnormality of embryologic development of anterior chamber (anterior chamber cleavage syndrome); remnants of hyaloid system; chorioretinal pigment surrounding optic disk; narrow branches of retinal arteries at edge of optic disk; retinal exudates and detachment; subretinal hemorrhages and retinal neovascularization; enlarged pink optic disk, funnel shaped with a central white fluffy dot; nerve head surrounded by elevated annulus of chorioretinal pigment, unilateral.

Clinical: Midline cranial facial defects such as hypertelorism, cleft lip/palate, basal encephalocele, agenesis of corpus callosum, sphenoid encephalocele defects in the floor of the sella turcica; cranial, facial, and neurologic associations; pituitary dwarfism; association with the CHARGE syndrome.

Caprioli J, Lesser RL. Basal encephalocele and morning glory syndrome. Br J Ophthalmol 1983; 67:349.

Chang S, et al. Treatment of total retinal detachment in morning glory syndrome. Am J Ophthalmol 1984; 97: 596-600.

Eustis HS, et al. Morning glory syndrome in children. Association with endocrine and central nervous system anomalies. Arch Ophthalmol 1994; 112:204-207.

Handemann M. Erbliche, Vermutlich Angeborene Zentrale Gliose Entartung des Sehnerven mit Besonderer Beteiligung der Zentralgefasse. Klin Monatsbl Augenheilkd 1929; 83:145.

Itakura T, et al. Bilateral morning glory syndrome associated with sphenoid encephalocele. Case report. J Neurosurg 1992; 77:949-951.

Kindler P. Morning glory syndrome: unusual congenital optic disc anomaly. Am J Ophthalmol 1970; 69:376.