Neuroblastoma

General: Highly malignant solid tumor ar 444g62e ising from undifferentiated sympathetic neuroblasts of the adrenal medulla, sympathetic ganglia, ectopic adrenal, and theoretically the ciliary ganglion; autosomal dominant.

Ocular: Ptosis; exophthalmos; proptosis; optic atrophy; optic neuritis; papilledema; metastatic tumor of orbit; retinal hemorrhage; convergent strabismus; paralysis of sixth or seventh nerve; nonreactive pupil; primary differentiated neuroblastoma of the orbit also has been reported; tonic pupils; microphthalmia; choroidal metastases (rare); iris metastases (rare).

Clinical: Skeletal metastasis to the cranium.

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