Neuroblastoma

General: Highly malignant solid tumor arising from undifferentiated sympathetic neuroblasts of the adrenal medulla, sympathetic ganglia, ectopic adrenal, and theoretically the ciliary ganglion; autosomal dominant.

Ocular: Ptosis; exophthalmos; proptosis; optic atrophy; optic neuritis; papilledema; metastatic tumor of orbit; retinal hemorrhage; convergent strabismus; paralysis of sixth or seventh nerve; nonreactive pupil; primary differentiated neuroblastoma of the orbit also has been reported; tonic pupils; microphthalmia; choroidal metastases (rare); iris metastases (rare).

Clinical: Skeletal metastasis to the cranium.

Blake J, Fitzpatrick C. Eye signs in neuroblastoma. Trans Ophthalmol Soc UK 1972; 92:825-833.

Fraunfelder FT, Roy FH. Current Ocular Therapy, 5th ed. Philadelphia: WB Saunders, 2000.

Haupt R, et al. Neuroblastoma IV-S in a patient with bilateral microphthalmia. Acta Paediatr 1993; 82:1085-l086.

Knudsen AG Jr, Meadows AT. Developmental genetics of neuroblastoma. J Natl Cancer Inst 1976; 57:675-682.

Volpe NJ, Albert DM. Metastases to the uvea. In: Albert D, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. V. Philadelphia: WB Saunders, 1994:3267.

West, Repka MX. Tonic pupils associated with neuroblastoma. J Pediatr Ophthalmol Strabismus 1992; 29:382-383.