Sjgren syndrome (gougerot-sjgren syndrome; secretoinhibitor syndrome; sicca syndrome) 1

General: Etiology unknown; autosomal recessive; occurs in women over age 40 years; failure of the lacrimal and conjunctiv 343f59d al glands to maintain adequate secretion; similarities exist with Mikulicz syndrome (see Mikulicz-Radecki Syndrome); insidious onset; associated with collagen disorders; Epstein-Barr virus infection.

Ocular: Blepharoconjunctivitis; tears show no lysozyme; keratoconjunctivitis sicca; superficial corneal ulcers; thready, tenacious, yellow-white discharge of the conjunctiva; hypertrophy of lacrimal gland; decreased tear secretion with cellular and mucous debris in tear film; cicatrization of cornea and conjunctiva.

Clinical: Dryness of mouth and other mucous membranes; enlarged salivary glands; dysphagia; painless swelling of joints; polyarthritis; dental cavities; vaginitis; laryngitis; rhinitis sicca; hepatomegaly; focal myositis; alopecia; splenomegaly.

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