Jacod Syndrome (Negri-Jacod Syndrome; Petrosphenoidal Space Syndrome)
General: Lesion involving cranial nerves II to VI; most frequently a malignant nasopharyngeal tum 858c24i or originating in lateropharyngeal area.
Ocular: Ophthalmoplegia; unilateral blindness; trigeminal neuralgia (ophthalmic branch); descending optic atrophy if cranial nerve II is involved; amaurosis fugax.
Clinical: Trigeminal neuralgia (at the beginning the first and second divisions of nerve V are involved; later the third division is affected as well); unilateral or bilateral enlargement of cervical lymph nodes (30%); deafness; palatal muscle paralysis.
Fischer A, et al. Familial nasopharyngeal carcinoma. Pathology 1984; 16:23-24.
Jacod M. Sur la Proation Intracranienne des Sarcomes de la Trompe d'Eustache Syndrome du Carrefour Petro-Sphenoidale Paralysie des 2, 3, 4, 5, et 6 Paires Craniennes. Rev Neurol l921; 38:33.
Riggs HE. Cranial nerve syndromes associated with nasopharyngeal malignancy. Arch Neurol Psychiatr 1957; 77: 473.
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